Career

About Ensem Therapeutics


ENSEM Therapeutics develops and applies pioneering novel Structural Ensemble platforms for transformative medicines. We focus on high value and difficult-to-drug oncology targets with significant unmet medical needs by uncovering non-obvious pockets for drug design. ENSEM is incubated by CBC Group (http://www.cbridgecap.com) and headquartered in Boston. The ENSEM team is fun, audacious, optimistic, and filled with wonder, creativity, and perseverance.

POSITION:

ENSEM Therapeutics is seeking an experienced and motivated PhD-level scientist specialized in protein X-ray crystallography to join our Shanghai-site Structure Biology team. In this role, you will manage as well as perform crystallographic experiments to help push forward our various structure-based drug design programs. Opportunities exist for additional contributions to other structural biology applications including NMR and CryoEM as well as various biophysical characterizations.

POSITION DESCRIPTION:

· Report to the Director of Structure Biology based in Boston and have the opportunities to manage research associates in Shanghai.
· Manage our CRO collaborations on recombinant protein design, expression and purification, and protein X-ray crystallography. This includes reviewing the weekly data, troubleshooting, and planning for weekly and longer-term action items.
· To participate in the downstream work of protein crystallography that includes refining small-molecule ligand-bound target complex structures and reporting/communicating the key structural findings to the team in writing and orally to aid in SBDD.
· To engage assay development colleagues and medicinal and computational chemists to design assays, analyze compound SARs, and triage compounds for crystallographic studies.
· To teamwork with internal colleagues to perform in-house

QUALIFICATIONS:

· A PhD in Chemistry, Biochemistry, or Biophysics specialized in protein X-ray crystallography with 4+ years of relevant training and strong publications as well as solid understanding of protein chemistry and small-molecule drug discovery principles. Familiarity with NMR or CryoEM is a plus but not required.
· Proficient in structural refinement and analysis to derive SBDD insights for med-chem designs as well as structure-mechanism hypotheses to help advance discovery projects; in protein design, expressions, purifications, and QCs; in protein/ligand co-crystallization, compound soaking, and cryoprotection. Experienced with in-person and mail-in synchrotron data collections.
· Flexibility, adaptability, and multi-tasking in an interdisciplinary, hybrid (internal/outsourcing) and multi-site environment.
· Exceptional interpersonal and communication skills to articulate deliverables, progresses, and issues to the drug discovery team and solicit feedbacks from team members and industrial and academic partners.
· Personal attributes: attention to details while focused on the big picture; ability to scientifically influence and motivate others; a team player who listens effectively and values feedbacks; collaborative, open-minded, data-driven, and creative; persistent, optimistic with can-do spirit.
· Exceptional Pharma/Biotech/CRO industrial veterans holding a MS degree and strong credentials are also encouraged to apply.

When submitting your application, please use Requisition Number ENSEM-2022-SB03 in your subject line. Submit your resume and a cover letter by clicking apply now.

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About the job:

Ensem Therapeutics is building new capabilities in Machine Learning (ML) and Artificial Intelligence (AI) on our computational platform for drug discovery. We are seeking a passionate and experienced Computational Scientist to join the team. The successful candidate will implement Ensem's strategy of integrating predictive sciences, biology, and medicinal chemistry to accelerate the path to new medicines. As a leader of the ML/AI team, you have the opportunity of being the architect of this transformative technology of drug discovery for the benefit of patients.

Job Responsibilities:

· Lead a team and develop cutting-edge machine learning algorithms and statistical models that enable and accelerate drug discovery projects.
· Build upon the successful protein structure prediction algorithms such as AlphaFold2 and Rosettafold, incorporate protein dynamics information from Ensem’s unique detailed experimental data and computer simulations into deep learning algorithms, to develop predictive models for non-obvious ligand-binding sites on protein targets, enable and impact new target identification and new mode of actions drugging strategies.
· Expend ML methodologies into the field of AI-based predicting ligand-protein recognition. Utilizing the structural information of protein-ligand complexes in PDB and combining with SAR from lead-optimization projects to generate accurate ligand binding-mode model and binding affinity prediction.
· Collaborate with computational chemists; develop and train machine learning models to improve the accuracy of traditional physics-based simulation and modeling methods.
· Develop ML/statistical models for predicting molecular properties based molecular structures · Develop generative models for designing drug-like molecules
· Work with scientific leadership at Ensem to develop the strategy for company success through platform technologies
· Build a productive team and develop the culture of scientific innovation.

Key Qualifications:

· Ph. D. in computational or physical sciences with 3+ years of working experiences. Drug-discovery experience is a plus.
· Notable accomplishments in machine learning research with strong publication record
· Extensive experience with common machine learning tools, such as Scikit.learn, Tensorflow, Pytorch, etc..
· Hand-on knowledge of working with large and heterogeneous data sets.
· Experience in collaboration with research scientists in biology and chemistry to solve scientific problems
· Experience with cheminformatic and bioinformatic tools.
· Strong leadership skills and mentorship.
· Highly motivated to develop computational methods and software for discovering better medicines

Personal Attributes:

· Flexibility and adaptability to thrive in an emerging biotech environment
· Sense of urgency to help bring new and more effective medicine to patients.
· Collaborative, open-minded, data-driven, and creative.
· Attention to details while focused on the big picture.
· Persistent in the face of obstacles and uncertainty, strongly optimistic about overcoming challenges.


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POSITIONS:

ENSEM Therapeutics is seeking experienced and motivated PhD-level scientists with expertise in cancer cell biology to join our Cell Biology team. In this role, you will design and perform cell studies to evaluate small molecules for their ability to inhibit oncogenic pathways. You will also assess novel drug targets for their prioritization and integration into our discovery pipeline.

POSITION DESCRIPTION:

· Report to the Head of Biology or one of our senior biologists.
· Design mechanistic assays for small molecule optimization and manage external resources for routine compound testing. Characterize lead compounds and development candidates to help advance projects to preclinical development and to enable development of biomarkers and assays for use in first-in-human studies.
· Actively participate in discussions at project meetings and other forums within the company, to leverage the opportunities to broaden scientific and strategic insights.
· Collaborate with colleagues from other functional areas to build and maintain alignment on project goals and issues. Scientists who demonstrate the requisite leadership skills will have future opportunity to lead project teams and manage internal resources.

QUALIFICATIONS:

· A PhD in Biology, Pharmacology, Cell or Molecular Biology with experience in signal transduction pathways or gene expression regulation in mammalian cells is required. Post-doctoral training is required, except in the case of Associate Scientists.
· Proficiency in the characterization of proteins and nucleic acids, using techniques such as immunoprecipitation, ELISA, RT-PCR, and qPCR is required. Candidates should have extensive experience with mammalian cell culture and transfection techniques, as well as the design of expression plasmids.
· Flexibility, adaptability, and multi-tasking in an interdisciplinary, hybrid (internal/outsourcing) and multi-site environment.
· Exceptional interpersonal and communication skills to articulate deliverables, progresses, and issues to the drug discovery team and solicit feedbacks from team members and industrial and academic partners.
· Personal attributes: attention to details while focused on the big picture; ability to scientifically influence and motivate others; a team player who listens effectively and values feedbacks; collaborative, open-minded, data-driven, and creative; persistent, optimistic with can-do spirit.

When submitting your application, please use Requisition Number ENSEM-2022-CB02 in your subject line. Submit your resume and a cover letter by clicking apply now.

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POSITION:

ENSEM Therapeutics is seeking experienced and motivated BS- or MS-level scientists with experience in cancer cell biology to join our Cell Biology team. In this role, you will design and perform cell studies to evaluate small molecules for their ability to inhibit oncogenic pathways.

POSITION DESCRIPTION:

· Report to one of our senior biologists.
· Optimize mechanistic assays that will be used by external resources in routine testing of small molecules. Characterize lead compounds and development candidates to help advance projects to preclinical development and to enable development of biomarkers and assays for use in first-in-human studies.
· Perform in vitro target knockdown or knockout studies for optimization of assays and reagents, and for target evaluation.
· Collaborate with colleagues from other functional areas to assist in data interpretation and reporting. Present experimental results in departmental and project team meetings.

QUALIFICATIONS:

· A BS degree (with 5+ years of experience), or an MS degree (with 3+ years of experience) in Biology, Pharmacology, Cell or Molecular Biology with experience in signal transduction pathways or gene expression regulation in mammalian cells is required.
· Proficiency in the characterization of proteins and nucleic acids, using techniques such as immunoprecipitation, ELISA, and RT-PCR is required. Candidates should have extensive experience with mammalian cell culture and transfection techniques.
· Flexibility, adaptability, and multi-tasking in an interdisciplinary, hybrid (internal/outsourcing) and multi-site environment.
· Exceptional interpersonal and communication skills to articulate deliverables, progresses, and issues to the drug discovery team and solicit feedbacks from team members and industrial and academic partners.
· Personal attributes: attention to details while focused on the big picture; ability to scientifically influence and motivate others; a team player who listens effectively and values feedbacks; collaborative, open-minded, data-driven, and creative; persistent, optimistic with can-do spirit.

When submitting your application, please use Requisition Number ENSEM-2022-CB03 in your subject line. Submit your resume and a cover letter by clicking apply now.

Apply Now

POSITION:

The Senior Administrative Assistant will report to the Vice President, Operations and be responsible for providing administrative support to members of the Executive Leadership team including the Chief Executive Officer and Chief Science Offer. This position will also supporting special projects and initiatives across and coordinate office activities.

POSITION DESCRIPTION:

• Arranging meetings, scheduling appointments, and managing complex calendars
• Directs office activities and functions to maintain efficiency and compliance with company policies.
• Assists clerical and support staff with their assigned duties, particularly when more advanced, skilled, or sensitive work is required.
• Prepares agendas, makes travel arrangements, and maintains calendars for senior management.
• In collaboration with the Operations team, coordinate new hire on-boarding logistics involving, but not limited to, ordering computer equipment, creating badges, etc. to facilitate a smooth on-boarding process for new hires
• Oversees telephone services, email correspondence, and mail distribution.
• Maintains office supplies inventory.
• Maintains records, documentation, and files, particularly more complex or sensitive files such as employee files.
• Maintaining working knowledge of relevant company policies and procedures; may act as a source of information on organizational policies and procedures.
• Performs other related duties as assigned.

QUALIFICATIONS:

• Associate’s degree in office administration or related field.
• Four years of experience as an administrative or equivalent supporting senior level executives
• Experience in the biotechnology industry is a plus
• Excellent verbal and written communication skills.
• Excellent organizational skills and attention to detail.
• Excellent time management skills with a proven ability to meet deadlines.
• Strong working knowledge of Microsoft Office Software. Expertise with Outlook required.
• Ability to prioritize tasks and to delegate them when appropriate.
• Ability to function well in a high-paced and at times stressful environment.

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